Dante's estranged brother, Vergil, will be returning to the series as a main character in Ninja Theory's DmC: Devil May Cry. More details and a trailer after the break.
Capcom announced his return during their pre-Gamescom press conference, explaining that Vergil recruits Dante into an organisation called The Order devoted to saving mankind from demonic enslavement. The two characters will work together in combat and bicker in cutscenes, but we don't yet know if Vergil will also be playable.
DmC: Devil May Cry will release on January 15th, 2013.